What are common therapy and surgery for skin diseases? Topical medicine Topical medicine is more effective for skin conditions. Topical medicine is applied directly to the skin lesion or affected area. Hence, the effect of the medicine is more on the affected area and its systemic effect is less. Topical medicine nourishes and protects the skin. Topical medicine is found in different forms like lotions, creams, gels, pastes, ointments, oils,