Children with Congenital Disorder of the Gastro intestinal (GI) system. Explain/ Define Cleft lip and Cleft palate Cleft lip and cleft palate are congenital malformations of the face caused by failure of fusion of the first brachial arch during intrauterine development.Cleft lip and cleft palate are usually seen due to failure of development of bony and soft tissue structures on one or both sides of the midline of the palate