πΆπ»π Cleft Lip Definition | Etiology | Pathophysiology πΉ Definition Cleft lip is a congenital craniofacial anomaly where there is a split or opening in the upper lip, due to incomplete fusion of facial structures during fetal development. It can range from a small notch in the lip to a complete gap that extends into the nostril. πΉ Etiology (Causes) Cleft lip results from a combination of genetic and environmental