UNIT 6 Oxygenation needs Oxygenation Needs of a Patient. Introduction to Oxygenation in Nursing Oxygenation is a fundamental physiological process necessary for cellular function and survival. It involves the intake of oxygen (O₂), transport via the circulatory system, and its utilization by tissues. Any alteration in oxygenation can lead to hypoxia, tissue damage, and life-threatening conditions. In nursing, ensuring adequate oxygenation is a core responsibility. Physiology of Oxygenation Oxygenation involves: