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Prevalence and Incidence of Mood Disorders Mood disorders, including major depressive disorder (MDD), bipolar disorder, and dysthymia, are among the most prevalent mental health conditions globally. Their prevalence and incidence vary based on factors such as geographic location, socioeconomic status, and access to mental health care. 1. Prevalence of Mood Disorders Prevalence refers to the total number of cases (both new and existing) of a condition in a population at