skip to main content

COH MIDWIFERY SYNOPSIS 1

IMP SYNOPSIS.

Structure and Layers of the Uterus, Decidua.

1. Structure of the Uterus

The uterus is a hollow, muscular organ of the female reproductive system, located in the pelvic cavity between the bladder and rectum. It is responsible for implantation, fetal development, and childbirth.

A. Anatomical Divisions of the Uterus:
  1. Fundus – The dome-shaped uppermost part.
  2. Body (Corpus Uteri) – The main portion of the uterus.
  3. Isthmus – The narrow region connecting the body and cervix.
  4. Cervix – The lower cylindrical portion that extends into the vagina.
B. Dimensions of the Uterus:
  • Nulliparous women: ~7.5 cm long, 5 cm wide, 2.5 cm thick.
  • Multiparous women: Slightly larger.
  • During pregnancy: Expands significantly to accommodate the growing fetus.

2. Layers of the Uterus

The uterus has three layers:

A. Perimetrium (Serosa)

  • The outermost layer of the uterus.
  • Formed by visceral peritoneum, covering the fundus and posterior part of the body.
  • Provides structural support and protection.

B. Myometrium

  • The thickest and middle muscular layer composed of smooth muscle fibers.
  • Essential for uterine contractions during labor and menstrual expulsion.
  • Three sublayers:
    1. Outer longitudinal layer – Helps in contraction during delivery.
    2. Middle crisscross layer – Rich in blood vessels (Stratum vasculare), prevents hemorrhage after childbirth.
    3. Inner circular layer – Prominent near the cervix, helps in cervical dilation.

C. Endometrium

  • The innermost mucosal layer that undergoes cyclic changes during the menstrual cycle.
  • Highly vascular and glandular, essential for implantation of the fertilized ovum.

Subdivisions of the Endometrium:

  1. Stratum Functionalis (Functional Layer)
    • Superficial layer that sheds during menstruation.
    • Responds to hormonal changes (estrogen & progesterone).
  2. Stratum Basalis (Basal Layer)
    • Deep layer, does not shed, responsible for regenerating the functionalis after menstruation.

3. Decidua – Modified Endometrium during Pregnancy

  • The decidua is the transformed endometrial lining during pregnancy due to the influence of progesterone.
  • It is essential for implantation, placental development, and maternal-fetal exchange.
Types of Decidua:
  1. Decidua Basalis
    • Located beneath the implanted embryo.
    • Forms the maternal part of the placenta.
  2. Decidua Capsularis
    • Covers the growing embryo, separating it from the uterine cavity.
    • Eventually fuses with the decidua parietalis and disappears.
  3. Decidua Parietalis
    • The remaining endometrial lining of the uterus.
    • Unites with the decidua capsularis by the 4th month of pregnancy.

4. Clinical and Competitive Exam Importance

AspectClinical Relevance
MyometriumContracts during labor, targeted by oxytocin.
EndometriumSite of implantation, sheds in menstruation, affected in endometriosis.
Decidua BasalisForms maternal placenta, involved in placental abnormalities like placenta accreta.
Decidua CapsularisProtects the embryo, later disappears.
Decidua ParietalisFuses with capsularis, significant in chorionic villi development.

5. Exam-Oriented Questions

Which layer of the uterus is responsible for contractions during labor?
👉 Myometrium

Which endometrial layer regenerates after menstruation?
👉 Stratum Basalis

What is the function of the decidua basalis?
👉 Forms the maternal part of the placenta

What happens to the decidua capsularis by the 4th month?
👉 It fuses with decidua parietalis and disappears.

Fallopian Tube and Its Parts.

1. Introduction to the Fallopian Tube

The Fallopian tubes (Uterine Tubes or Oviducts) are paired, slender, muscular tubes that extend from the uterus to the ovaries, facilitating the transport of ova (eggs) from the ovary to the uterus. They are the site of fertilization and play a crucial role in early embryonic development.

A. Location and Structure:
  • Length: ~10–12 cm
  • Diameter: 2–4 mm
  • Situated in the upper free margin of the broad ligament.
  • Opens into the peritoneal cavity near the ovary.
  • Lined with ciliated columnar epithelium and secretory cells.

2. Parts of the Fallopian Tube

The Fallopian tube has four major parts, each with distinct functions:

A. Infundibulum

  • Funnel-shaped distal end that is closest to the ovary.
  • Has fimbriae – finger-like projections that help capture the ovum after ovulation.
  • Abdominal ostium (opening) allows direct communication with the peritoneal cavity.
  • Clinical Significance:
    • Possible site for ectopic pregnancy.
    • Open communication with the peritoneal cavity can lead to pelvic infections (PID).

B. Ampulla

  • Longest and widest part (~5 cm in length).
  • The site of fertilization (usually within 12–24 hours of ovulation).
  • Lined with ciliated epithelium to assist in egg movement.
  • Clinical Significance:
    • Most common site of ectopic pregnancy.
    • Blockage can lead to infertility.

C. Isthmus

  • Narrow, thick-walled portion (~3 cm in length).
  • Connects the ampulla to the uterus.
  • Less convoluted, with a smaller lumen.
  • Helps in transporting the fertilized ovum to the uterus.
  • Clinical Significance:
    • Tubal ligation (sterilization) is usually performed at the isthmus.

D. Interstitial (Intramural) Part

  • The shortest portion, located within the muscular wall of the uterus (~1 cm).
  • Opens into the uterine cavity via the uterine ostium.
  • Clinical Significance:
    • Interstitial ectopic pregnancy can be life-threatening due to excessive bleeding.

3. Layers of the Fallopian Tube

The Fallopian tube has three layers:

LayerDescriptionFunction
Serosa (Peritoneal Covering)Outer protective layerReduces friction.
MuscularisSmooth muscle layerHelps in peristalsis and ciliary movements for ovum transport.
MucosaInner ciliated epitheliumMoves egg and nourishes it.

4. Functions of the Fallopian Tube

  1. Ovum Transport: Fimbriae capture the ovum; cilia and peristalsis move it towards the uterus.
  2. Fertilization Site: Occurs in the ampulla within 12–24 hours post-ovulation.
  3. Nourishment: Secretory cells provide nutrients for the ovum and embryo.
  4. Sperm Transport: Helps in sperm capacitation for fertilization.

5. Clinical and Competitive Exam Importance

AspectClinical Relevance
FimbriaeCapture ovum; failure can lead to ectopic pregnancy.
AmpullaMost common site of fertilization and ectopic pregnancy.
IsthmusCommon site for tubal ligation (sterilization).
Interstitial partDangerous site for ectopic pregnancy due to heavy bleeding risk.
Ciliated epitheliumDysfunction can lead to infertility.

6. Exam-Oriented Questions

Which part of the Fallopian tube is responsible for capturing the ovum?
👉 Fimbriae of the Infundibulum

Where does fertilization usually occur?
👉 Ampulla of the Fallopian tube

Which part of the Fallopian tube is most commonly ligated for female sterilization?
👉 Isthmus

Which part of the Fallopian tube is located inside the uterus?
👉 Interstitial part

What is the function of the ciliated epithelium in the Fallopian tube?
👉 To facilitate the movement of the ovum towards the uterus.

Breast


1. Introduction to the Breast

The breast (Mammary Gland) is a paired, modified sweat gland that functions as an exocrine gland. It plays a crucial role in lactation (milk production and secretion) and undergoes significant changes during puberty, pregnancy, and menopause.

A. Location and Structure:
  • Situated in the anterior chest wall, extending from 2nd to 6th ribs and from the sternum to the midaxillary line.
  • Lies over the pectoralis major muscle and partially over the serratus anterior.
  • The axillary tail of Spence extends into the axilla (armpit).
  • Highly vascularized, supplied mainly by the internal thoracic artery, lateral thoracic artery, and intercostal arteries.

2. Structure of the Breast

The breast consists of three main components:

ComponentDescription
Glandular tissueProduces and secretes milk.
Fibrous connective tissueSupports the glandular tissue.
Adipose (fatty) tissueProvides size, shape, and cushioning.
A. Glandular Structure – Lobes and Lobules
  • The breast contains 15–20 lobes, each separated by fibrous septa (Cooper’s ligaments).
  • Each lobe consists of multiple lobules, containing alveoli that produce milk.
  • Milk is transported via lactiferous ducts, which open at the nipple.
B. Nipple and Areola
  • The nipple (Papilla Mammaria) contains lactiferous duct openings.
  • The areola is a pigmented circular area around the nipple containing Montgomery’s glands, which secrete an oily substance to lubricate the nipple during lactation.

3. Layers of the Breast

LayerDescription
SkinOuter covering, contains nipple and areola.
Subcutaneous TissueRich in fat, determines size.
Glandular TissueProduces and secretes milk.
Fibrous Connective TissueSupports breast structure (Cooper’s ligaments).
Retromammary SpaceSeparates breast from pectoralis major muscle.

4. Functions of the Breast

  1. Lactation – Production and secretion of milk under hormonal control.
  2. Nourishment of the newborn – Rich in essential nutrients and antibodies.
  3. Immune protectionColostrum provides maternal antibodies (IgA).
  4. Hormonal response – Changes occur due to estrogen, progesterone, prolactin, and oxytocin.

5. Hormonal Regulation of Breast Function

HormoneFunction
EstrogenStimulates ductal growth and fat deposition.
ProgesteroneStimulates lobular and alveolar development.
ProlactinInitiates milk production (lactogenesis).
OxytocinCauses milk ejection (let-down reflex).
Human Placental Lactogen (hPL)Prepares the breast for lactation during pregnancy.

6. Clinical and Competitive Exam Importance

AspectClinical Relevance
Axillary Tail of SpenceSite of breast cancer spread.
Cooper’s LigamentsShortening leads to skin dimpling in breast cancer.
Montgomery’s GlandsSecrete protective lubricant for nipple.
Retromammary SpaceAllows breast mobility; invasion can indicate advanced malignancy.
ColostrumFirst milk, rich in IgA, protects newborns.

7. Exam-Oriented Questions

What is the functional unit of the breast?
👉 Lobules (Alveoli) within lobes

Which hormone is responsible for milk ejection?
👉 Oxytocin

What is the significance of the Axillary Tail of Spence?
👉 Common site of breast cancer metastasis

Which structure supports the breast and is responsible for dimpling in cancer?
👉 Cooper’s Ligaments

Which hormone initiates milk production?
👉 Prolactin

Menstrual Disorders


1. Introduction to Menstrual Disorders

Menstrual disorders refer to abnormalities in the menstrual cycle, including irregular cycles, excessive bleeding, painful periods, and absence of menstruation. These disorders can result from hormonal imbalances, structural abnormalities, lifestyle factors, or underlying medical conditions.

Normal Menstrual Cycle:

  • Cycle Length: 21–35 days (Average: 28 days)
  • Duration of Bleeding: 2–7 days
  • Blood Loss: 30–80 mL

2. Classification of Menstrual Disorders

Menstrual disorders can be classified into seven major types:

A. Amenorrhea (Absence of Menstruation)

👉 Definition: The absence of menstrual periods for three or more consecutive cycles.
👉 Types:

  1. Primary Amenorrhea:
    • Absence of menarche by 15 years in the presence of secondary sexual characteristics OR
    • No menstruation by 13 years without secondary sexual characteristics.
    • Causes:
      • Turner syndrome (45,XO)
      • Mullerian agenesis
      • Androgen insensitivity syndrome
      • Hypothalamic dysfunction
      • Pituitary disorders (e.g., Prolactinoma)
  2. Secondary Amenorrhea:
    • Absence of menstruation for 6 months in a previously menstruating woman.
    • Causes:
      • Pregnancy (most common cause)
      • PCOS (Polycystic Ovarian Syndrome)
      • Hyperprolactinemia
      • Premature ovarian failure
      • Hypothyroidism

B. Oligomenorrhea (Infrequent Menstruation)

👉 Definition: Menstrual cycles longer than 35 days but less than 6 months.
👉 Causes:

  • PCOS
  • Thyroid disorders
  • Hyperprolactinemia
  • Excessive exercise, stress, anorexia

C. Polymenorrhea (Frequent Menstruation)

👉 Definition: Cycles shorter than 21 days.
👉 Causes:

  • Luteal phase defect
  • Pelvic inflammatory disease (PID)
  • Endometriosis

D. Menorrhagia (Heavy Menstrual Bleeding)

👉 Definition: Prolonged (>7 days) or excessive (>80 mL) bleeding in regular cycles.
👉 Causes:

  • Uterine fibroids
  • Endometrial hyperplasia
  • Adenomyosis
  • Hypothyroidism
  • Von Willebrand disease (bleeding disorder)

E. Metrorrhagia (Irregular Bleeding)

👉 Definition: Bleeding at irregular intervals outside the normal cycle.
👉 Causes:

  • Endometrial polyps
  • Cervical or endometrial cancer
  • Hormonal imbalance
  • Uterine fibroids

F. Hypomenorrhea (Scanty Menstruation)

👉 Definition: Minimal bleeding (<30 mL) with regular cycles.
👉 Causes:

  • Asherman’s Syndrome (uterine adhesions after D&C)
  • Ovarian insufficiency
  • Chronic endometritis

G. Dysmenorrhea (Painful Menstruation)

👉 Definition: Severe lower abdominal pain during menstruation.
👉 Types:

  1. Primary Dysmenorrhea:
    • Pain without pelvic disease, caused by excess prostaglandins.
    • Begins within 6–12 months after menarche.
    • Relieved by NSAIDs, exercise, and heat therapy.
  2. Secondary Dysmenorrhea:
    • Due to underlying conditions (e.g., endometriosis, fibroids, PID).
    • Pain worsens over time and is not relieved by usual treatments.

3. Causes of Menstrual Disorders

CategoryExamples
Hormonal DisordersPCOS, Hyperprolactinemia, Thyroid disorders, Ovarian failure
Structural AbnormalitiesFibroids, Endometriosis, Adenomyosis, Uterine polyps
Blood DisordersVon Willebrand Disease, Clotting disorders
MedicationsAnticoagulants, Hormonal contraceptives, Chemotherapy drugs
Lifestyle FactorsExcessive exercise, Stress, Malnutrition, Obesity

4. Diagnosis of Menstrual Disorders

History Taking:

  • Age of menarche
  • Cycle regularity and duration
  • Associated symptoms (pain, infertility, weight gain/loss, discharge, etc.)
  • Family history of bleeding disorders or endocrine diseases

Physical Examination:

  • BMI and signs of hormonal imbalance (e.g., hirsutism, acne in PCOS)
  • Pelvic examination for masses or tenderness

Investigations:

  1. Hormonal Tests:
    • FSH, LH (Ovarian function)
    • Prolactin (Hyperprolactinemia)
    • TSH (Thyroid disorders)
    • Estrogen & Progesterone levels
  2. Ultrasound (USG):
    • Detects PCOS, fibroids, endometrial thickness
  3. Endometrial Biopsy:
    • In cases of postmenopausal bleeding or suspected endometrial hyperplasia
  4. Hysteroscopy:
    • Direct visualization of endometrial cavity

5. Treatment of Menstrual Disorders

A. Medical Treatment

ConditionTreatment
Primary DysmenorrheaNSAIDs (Ibuprofen), Oral Contraceptive Pills (OCPs)
PCOSLifestyle changes, OCPs, Metformin
MenorrhagiaTranexamic acid, Progesterone therapy
Amenorrhea (due to hypothyroidism)Thyroid hormone replacement
EndometriosisHormonal therapy (GnRH analogs), Surgery
FibroidsOCPs, Myomectomy, Uterine artery embolization

B. Surgical Treatment

  • Dilation and Curettage (D&C) – For endometrial hyperplasia.
  • Hysteroscopy & Laparoscopy – For fibroids, polyps, and adhesions.
  • Hysterectomy – Last option for severe cases of fibroids, adenomyosis, and malignancies.

6. Clinical and Competitive Exam Importance

AspectClinical Relevance
Primary AmenorrheaSeen in Turner syndrome, Mullerian agenesis.
Secondary AmenorrheaPregnancy most common cause, followed by PCOS.
DysmenorrheaPrimary: Excess prostaglandins; Secondary: Endometriosis.
MenorrhagiaLinked to fibroids, thyroid disorders, clotting disorders.
PolymenorrheaShort cycles, commonly due to PID, luteal phase defect.

7. Exam-Oriented Questions

What is the most common cause of secondary amenorrhea?
👉 Pregnancy

Which menstrual disorder is commonly seen in PCOS?
👉 Oligomenorrhea (Infrequent menstruation)

What is the most common cause of menorrhagia in women over 40 years?
👉 Uterine fibroids

What is the primary cause of dysmenorrhea?
👉 Increased prostaglandin production

What is the best investigation for PCOS?
👉 Ultrasound (USG) showing multiple ovarian cysts

Maternal Pelvis and Fetal Skull


1. Maternal Pelvis

The maternal pelvis is a bony structure that plays a critical role in childbirth (labor and delivery). It supports the weight of the body, protects pelvic organs, and provides the birth canal for the passage of the fetus.

A. Parts of the Pelvis

The pelvis consists of four bones:

  1. Two Innominate Bones (Hip Bones) – Formed by the ilium, ischium, and pubis.
  2. Sacrum – Five fused vertebrae.
  3. Coccyx – Four fused vertebrae.

B. Types of Pelvis

The Caldwell-Moloy Classification categorizes the female pelvis into four types based on shape:

TypeFeaturesIncidenceObstetric Importance
Gynecoid (Ideal for Delivery)Round shape, wide subpubic arch, well-curved sacrum50%Most favorable for normal vaginal delivery
Android (Male-type Pelvis)Heart-shaped, narrow subpubic arch, prominent ischial spines20%Difficult labor (Arrest of Descent, Forceps Delivery, C-section needed)
AnthropoidOval shape, AP diameter longer than transverse, narrow pelvic outlet25%Can lead to persistent occipito-posterior position
PlatypelloidFlat pelvis, shortened AP diameter, wide transverse diameter5%Transverse arrest, often requires C-section

C. Diameters of the Maternal Pelvis

The pelvic diameters are critical in labor as they determine the ease of fetal passage.

1. Pelvic Inlet Diameters

DiameterLength (cm)Significance
Anteroposterior (True Conjugate)11 cmNarrowest fixed diameter
Obstetric Conjugate10.5 cmMeasured clinically, crucial for fetal passage
Diagonal Conjugate12.5 cmMeasured via per vaginal examination
Transverse Diameter13.5 cmWidest diameter of pelvic inlet

2. Pelvic Midplane Diameters

DiameterLength (cm)Significance
Interspinous Diameter10 cmNarrowest part of midpelvis, determines fetal head descent
Anteroposterior Diameter12 cmFrom pubic symphysis to sacrum

3. Pelvic Outlet Diameters

DiameterLength (cm)Significance
Anteroposterior (Sacrococcygeal to Symphysis Pubis)13 cmIncreases due to coccyx movement during labor
Transverse (Intertuberous)11 cmMeasured between ischial tuberosities

D. Clinical Significance of Maternal Pelvis

Gynecoid pelvis is the most favorable for vaginal delivery.
Android pelvis is associated with arrest of labor and requires instrumental delivery or C-section.
Pelvimetry (assessment of pelvic diameters) is crucial in cases of cephalopelvic disproportion (CPD).
Interspinous diameter (10 cm) is the narrowest fixed diameter of the pelvis.


2. Fetal Skull

The fetal skull is the largest and most rigid part of the fetus that needs to pass through the birth canal. Its size, shape, and flexibility are important factors influencing labor.

A. Regions of the Fetal Skull

  • Vault (Cranium) – Formed by frontal, parietal, occipital, and temporal bones.
  • Base – Forms the lower part of the skull and is rigid.
  • Face – Does not participate in molding.

B. Sutures and Fontanelles

👉 Sutures: Fibrous joints between skull bones that allow molding during birth.

SutureLocationSignificance
SagittalBetween two parietal bonesHelps in molding
CoronalBetween frontal and parietal bones
LambdoidBetween occipital and parietal bones

👉 Fontanelles: Soft membranous gaps at skull junctions.

FontanelleShapeCloses byImportance
Anterior Fontanelle (Bregma)Diamond18 monthsUsed for fetal head assessment
Posterior Fontanelle (Lambda)Triangular6-8 weeks

C. Diameters of the Fetal Skull

Diameters of the fetal head determine engagement and passage through the birth canal.

DiameterLength (cm)PresentationSignificance
Suboccipitobregmatic9.5 cmVertex (Flexed Head)Ideal for normal delivery
Occipitofrontal11.5 cmPartially deflexedMay cause labor difficulty
Mentofrontal11.5 cmBrowUnfavorable for vaginal delivery
Submentobregmatic9.5 cmFaceNeeds C-section
Biparietal9.5 cmWidest transverse diameterDetermines fetal head engagement

D. Fetal Skull Molding and Engagement

Molding – Overlapping of skull bones to reduce head size for birth.
Engagement – The passage of the biparietal diameter through the pelvic inlet (first sign of labor progression).
Cephalic Presentation (Head-first) is the most common fetal presentation.


3. Clinical and Competitive Exam Importance

AspectClinical Relevance
Suboccipitobregmatic diameterSmallest diameter, ideal for vaginal delivery
Biparietal diameterUsed to assess engagement
Gynecoid pelvisBest for normal delivery
Android pelvisCauses arrest of labor
Platypelloid pelvisCommonly leads to C-section
MoldingHelps in reducing fetal skull size for passage

4. Exam-Oriented Questions

Which pelvis type is most favorable for normal delivery?
👉 Gynecoid pelvis

What is the narrowest fixed diameter of the pelvis?
👉 Interspinous diameter (10 cm)

Which fetal skull diameter is the smallest and most favorable for normal delivery?
👉 Suboccipitobregmatic (9.5 cm)

What is the most common type of pelvis?
👉 Gynecoid pelvis (50%)

Which part of the fetal skull undergoes molding?
👉 Vault (Cranium)

Which fetal skull presentation is most difficult for vaginal delivery?
👉 Brow presentation (Mentofrontal diameter – 11.5 cm)

Methods of Obstetric Examination


1. Introduction to Obstetric Examination

Obstetric examination is systematic clinical assessment of a pregnant woman to evaluate fetal well-being, position, and presentation for safe delivery. It includes history-taking, general examination, abdominal examination, and vaginal examination.

Components of Obstetric Examination

  1. General Examination
    • Vital signs: Blood pressure, pulse, temperature.
    • Weight gain: Normal pregnancy weight gain is 11–15 kg.
    • Edema assessment: Suggests preeclampsia if present.
  2. Obstetric Examination
    • Abdominal Palpation (Leopold’s Maneuvers)
    • Fundal Height Measurement
    • Fetal Heart Sound (FHS) Assessment
    • Pelvic Examination (Internal examination)

2. Methods of Abdominal Palpation (Leopold’s Maneuvers)

Leopold’s maneuvers help assess fetal lie, presentation, position, and engagement.

Leopold’s ManeuverMethodClinical Significance
First Maneuver (Fundal Grip)Hands placed over the fundusDetermines fetal lie (longitudinal, oblique, transverse)
Second Maneuver (Umbilical Grip)Hands on lateral sides of abdomenLocates fetal back & limbs, helps in auscultating FHS
Third Maneuver (Pawlik’s Grip)One hand above the symphysis pubisAssesses presenting part (head or breech)
Fourth Maneuver (Pelvic Grip)Hands at pelvic inletDetermines fetal engagement in the pelvis

Clinical Correlation:

  • If the fetal head is ballotable, it is not engaged.
  • If the fetal back is felt on the left side, the position is LOA (Left Occipito-Anterior).

3. Fetal Lie, Presentation, Denominator, and Position

A. Fetal Lie

👉 Definition: Relationship of the fetal long axis to the maternal long axis.
Types of Lie:

  1. Longitudinal LieHead or breech presents first (most common).
  2. Transverse Lie – Fetal long axis is perpendicular to maternal axis.
  3. Oblique LieIntermediate between longitudinal and transverse.

Clinical Correlation:

  • Transverse lie is incompatible with vaginal delivery, requiring C-section.
  • Oblique lie may correct spontaneously but can persist in multigravida women.

B. Fetal Presentation

👉 Definition: Part of the fetus closest to the birth canal.

TypeDescriptionIncidenceClinical Relevance
Cephalic (Head-first)Vertex (most common), Brow, Face96%Best for vaginal delivery
Breech (Buttocks-first)Frank, Complete, Footling3–4%Higher risk of C-section
Shoulder (Transverse lie)Shoulder or arm presenting1%Always requires C-section

Clinical Correlation:

  • Brow presentation (diameter 13.5 cm) usually leads to obstructed labor.
  • Face presentation can be delivered vaginally if mento-anterior.

C. Denominator

👉 Definition: A fixed reference point on the presenting part, used to describe fetal position.

PresentationDenominator
VertexOcciput
BrowFrontal bone
FaceMentum (Chin)
BreechSacrum
ShoulderAcromion (Scapula)

Clinical Correlation:

  • Occiput is the best denominator for normal labor progress.
  • Mentum posterior face presentation cannot deliver vaginally.

D. Fetal Position

👉 Definition: The relationship of the fetal denominator to the maternal pelvis.

Position is named using:

  1. Left or Right (L/R) – Indicates which side of the mother the denominator is on.
  2. Occiput, Sacrum, Mentum, or Acromion – Denominator.
  3. Anterior, Posterior, or Transverse – Location in the pelvis.
PositionDenominatorClinical Significance
LOA (Left Occipito-Anterior)OcciputMost common and favorable for normal delivery
ROP (Right Occipito-Posterior)OcciputLeads to prolonged labor, back pain
LST (Left Sacro-Transverse)SacrumBreech position, C-section needed
RMT (Right Mentum-Transverse)MentumFace presentation

Clinical Correlation:

  • LOA is the most favorable position for vaginal delivery.
  • Occipito-posterior positions (ROP, LOP) lead to prolonged labor and back pain.

4. Fetal Engagement

👉 Definition: The passage of the biparietal diameter (9.5 cm) through the pelvic inlet.

Signs of Engagement:

  • Head is fixed in the pelvis and cannot be easily moved.
  • Abdominal palpation: Fetal head cannot be felt above the pubic symphysis.
  • Per vaginal examination: Head felt at Station 0.

Clinical Correlation:

  • Engagement usually occurs by 36 weeks in primigravida.
  • In multiparous women, engagement can occur during labor.
  • Failure to engage suggests cephalopelvic disproportion (CPD).

5. Clinical and Competitive Exam Importance

AspectClinical Relevance
Leopold’s maneuversUsed to determine fetal lie, presentation, and engagement
LOA positionBest for vaginal delivery
ROP/LOP positionCauses prolonged labor and back pain
Transverse lieAlways requires C-section
Mentum posterior face presentationIncompatible with vaginal delivery
Shoulder presentationNeeds emergency C-section

6. Exam-Oriented Questions

Which fetal position is most favorable for normal vaginal delivery?
👉 Left Occipito-Anterior (LOA)

Which maneuver determines fetal lie?
👉 First Leopold’s Maneuver (Fundal Grip)

Which denominator is used for cephalic presentation?
👉 Occiput

What is the most common fetal presentation?
👉 Vertex (Cephalic) Presentation

Which presentation is associated with the highest risk of birth trauma?
👉 Breech presentation (especially footling breech)

Which fetal lie is incompatible with vaginal delivery?
👉 Transverse Lie

Development of Zygote and Placenta


1. Introduction to Zygote Development

The zygote is the single-cell fertilized ovum, which undergoes cell division, differentiation, and implantation to form the embryo and placenta.

Normal Fertilization Process:

  • Occurs in the Ampulla of the Fallopian tube.
  • Sperm penetrates the ovum, forming a diploid zygote (46 chromosomes).
  • Zona Pellucida prevents polyspermy (entry of multiple sperm).
  • Sex determination occurs at fertilization (XX = female, XY = male).

2. Stages of Zygote Development

StageDay Post-FertilizationKey Events
ZygoteDay 1Single-cell fertilized egg
CleavageDay 2–3Rapid mitotic division
Morula (16–32 cells)Day 3Solid ball of cells
BlastocystDay 5Fluid-filled cavity, ready for implantation
ImplantationDay 6–7Blastocyst attaches to the endometrium
GastrulationWeek 2–3Formation of three germ layers
Embryo FormationWeek 4–8Organogenesis begins

Clinical Correlation:

  • Implantation failure leads to early pregnancy loss.
  • Ectopic pregnancy occurs if the blastocyst implants outside the uterus (most commonly in the Fallopian tube).

3. Development of the Placenta

The placenta is a temporary organ that develops during pregnancy to supply nutrients and oxygen to the fetus.

A. Normal Development of the Placenta

StageTimeframeKey Features
Trophoblast DifferentiationWeek 2Forms Cytotrophoblast & Syncytiotrophoblast
Chorionic Villi FormationWeek 3Villi invade maternal blood vessels
Placentation CompletionWeek 12Fully developed maternal-fetal circulation

Fetal Side: Smooth, covered by amnion (umbilical cord attaches here).
Maternal Side: Rough, made up of 15–20 cotyledons.


4. Functions of the Placenta

FunctionDetails
NutritionTransfers glucose, amino acids, lipids to the fetus.
RespirationOxygen supply and CO₂ removal (acts as fetal lungs).
ExcretionRemoves fetal waste products via maternal circulation.
Hormone ProductionSecretes hCG, Estrogen, Progesterone, hPL.
Immune ProtectionTransfers maternal IgG antibodies to fetus.
Barrier FunctionPrevents entry of maternal cells into fetal circulation.

Clinical Correlation:

  • hCG (human Chorionic Gonadotropin) is detected in pregnancy tests.
  • hPL (Human Placental Lactogen) regulates fetal glucose metabolism.

5. Abnormalities of Placental Development

DisorderDescriptionClinical Significance
Placenta PreviaPlacenta implants over cervixCauses painless vaginal bleeding in late pregnancy, requires C-section
Placental AbruptionPremature separation of placentaCauses painful vaginal bleeding, fetal distress
Placenta AccretaAbnormal placental attachment to myometriumLeads to postpartum hemorrhage, requires hysterectomy
Placenta IncretaPlacenta invades deeper into myometriumCauses severe hemorrhage
Placenta PercretaPlacenta penetrates the uterine wallCan cause uterine rupture

Risk Factors: Previous C-section, uterine scarring, multiple pregnancies.


6. Abnormalities of Zygote Development

DisorderCauseClinical Features
Ectopic PregnancyImplantation outside the uterusSevere abdominal pain, vaginal bleeding
Molar Pregnancy (Hydatidiform Mole)Abnormal trophoblastic proliferationHigh hCG levels, grape-like vesicles on ultrasound
Anembryonic Pregnancy (Blighted Ovum)Fertilized egg develops without embryoEmpty gestational sac on ultrasound
Congenital MalformationsTeratogens, genetic defectsNeural tube defects, cardiac anomalies

Clinical Correlation:

  • Ultrasound confirms ectopic pregnancy before rupture.
  • Molar pregnancy can lead to choriocarcinoma if untreated.

7. Disorders of Placental Function

DisorderCauseClinical Effects
Fetal Growth Restriction (FGR/IUGR)Placental insufficiencyLow birth weight, hypoxia
Gestational Hypertension (Preeclampsia)Placental vascular dysfunctionHigh BP, proteinuria, edema
Twin-Twin Transfusion Syndrome (TTTS)Unequal blood flow in monochorionic twinsOne twin becomes polycythemic, the other anemic

Clinical Correlation:

  • Doppler ultrasound helps assess placental blood flow.
  • Aspirin may be given to prevent preeclampsia in high-risk women.

8. Clinical and Competitive Exam Importance

AspectClinical Relevance
Trophoblast invasion failureLeads to preeclampsia, IUGR
hCG productionMonitored in early pregnancy and molar pregnancy
Placenta previaCauses painless bleeding, requires C-section
Placental abruptionCauses painful bleeding, fetal distress
Fetal growth restriction (IUGR)Due to placental insufficiency

9. Exam-Oriented Questions

Where does fertilization normally occur?
👉 Ampulla of the Fallopian tube

Which hormone maintains pregnancy in the first trimester?
👉 hCG (Human Chorionic Gonadotropin)

What is the most common site of ectopic pregnancy?
👉 Fallopian tube (Ampulla)

Which placental abnormality causes painless bleeding in the third trimester?
👉 Placenta previa

What is the major function of the placenta?
👉 Oxygen and nutrient transfer to the fetus

Which condition occurs due to abnormal trophoblastic proliferation?
👉 Molar pregnancy (Hydatidiform mole)

Which antibody crosses the placenta to provide immunity?
👉 IgG

Development of Embryo and Fetus


1. Introduction to Embryonic and Fetal Development

The development of a human begins with fertilization, followed by zygote formation, embryogenesis, and fetal growth. It occurs in three stages:

  1. Germinal Stage (0–2 weeks) – Fertilization, cleavage, blastocyst formation, implantation.
  2. Embryonic Stage (3–8 weeks) – Organogenesis, formation of major body systems.
  3. Fetal Stage (9 weeks – birth) – Growth, differentiation, and maturation of organs.

Gestation Period: 40 weeks (280 days) from the Last Menstrual Period (LMP).
Trimesters:

  • First Trimester (Weeks 1–12): Organogenesis, critical period for malformations.
  • Second Trimester (Weeks 13–28): Rapid growth, fetal movements felt.
  • Third Trimester (Weeks 29–40): Organ maturation, weight gain, lung development.

2. Stages of Embryonic Development

StageWeekKey Events
ZygoteDay 1Single-cell formed after fertilization.
MorulaDay 316-cell solid ball.
BlastocystDay 5Hollow sphere, implantation occurs.
GastrulationWeek 3Formation of three germ layers (Ectoderm, Mesoderm, Endoderm).
NeurulationWeek 4Neural tube formation (brain & spinal cord).
OrganogenesisWeek 4–8Major organ systems develop.

Clinical Correlation:

  • Neural tube defects (Spina bifida, anencephaly) occur if folic acid deficiency is present.
  • Congenital heart defects develop if teratogens act during week 4–7.

3. Germ Layers and Their Derivatives

Germ LayerOrgans Derived
Ectoderm (Outer Layer)CNS (Brain, Spinal Cord), PNS, Skin, Hair, Nails, Eyes, Ears, Enamel, Pituitary Gland.
Mesoderm (Middle Layer)Muscles, Bones, Heart, Blood Vessels, Kidneys, Gonads, Lymphatics.
Endoderm (Inner Layer)Gastrointestinal Tract, Liver, Pancreas, Lungs, Thyroid, Bladder.

Clinical Correlation:

  • Cleft palate, heart defects, neural tube defects arise due to errors in embryonic folding.
  • Vertebral defects (e.g., Spina Bifida) occur if mesoderm fails to close around the neural tube.

4. Fetal Development – Week by Week

First Trimester (Weeks 1–12)

WeekDevelopmental Milestone
Week 3Primitive streak, neural plate formation.
Week 4Heart starts beating, limb buds form.
Week 5Brain, spinal cord, eye development.
Week 6Facial features begin forming.
Week 7Digits form, fetal heartbeat detected by ultrasound.
Week 8All major organs develop (Organogenesis completes).
Week 9Fetus starts moving, ossification begins.

Clinical Correlation:

  • Teratogens (alcohol, radiation, infections) are most dangerous during weeks 3–8.
  • Thalidomide exposure causes limb malformations during this period.

Second Trimester (Weeks 13–28)

WeekDevelopmental Milestone
Week 12External genitalia develop (Sex determination via ultrasound).
Week 16Quickening (fetal movements felt by mother).
Week 20Vernix caseosa (skin protection) and lanugo (fine hair) appear.
Week 24Lungs start producing surfactant, fetal viability increases.

Clinical Correlation:

  • Low amniotic fluid (Oligohydramnios) can lead to pulmonary hypoplasia.
  • Surfactant deficiency leads to Neonatal Respiratory Distress Syndrome (NRDS).

Third Trimester (Weeks 29–40)

WeekDevelopmental Milestone
Week 28Eyelids open, brain grows rapidly.
Week 32Fetus gains subcutaneous fat, better thermoregulation.
Week 36Fetal lungs mature, position fixed in cephalic presentation.
Week 40Term birth, full organ maturity.

Clinical Correlation:

  • Preterm birth (<37 weeks) leads to respiratory distress, hypothermia, feeding issues.
  • Macrosomia (>4 kg birth weight) is common in gestational diabetes.

5. Abnormalities of Fetal Development

DisorderCauseClinical Effects
Neural Tube DefectsFolic acid deficiencySpina bifida, anencephaly
Congenital Heart DefectsGenetic, viral infectionsTetralogy of Fallot, ASD, VSD
Limb MalformationsThalidomide exposurePhocomelia (missing limbs)
OligohydramniosLow amniotic fluidPotter’s syndrome (renal agenesis)
PolyhydramniosExcess amniotic fluidAssociated with esophageal atresia
IUGR (Intrauterine Growth Restriction)Placental insufficiencyLow birth weight, fetal distress

Clinical Correlation:

  • Prenatal screening (ultrasound, genetic tests) detects congenital abnormalities early.
  • Maternal infections (TORCH – Toxoplasmosis, Rubella, Cytomegalovirus, Herpes) can cause fetal malformations.

6. Fetal Circulation and Adaptations

The fetus has a unique circulation system to bypass non-functioning lungs.

Fetal Circulation Pathway

  1. Oxygenated blood from placenta → Umbilical vein → Ductus venosus → Inferior vena cava → Right atrium.
  2. Right atrium → Foramen ovale → Left atrium → Left ventricle → Aorta → Body.
  3. Deoxygenated blood → Umbilical arteries → Placenta for oxygenation.

Postnatal Adaptations

StructureFunction in FetusChanges After Birth
Ductus VenosusShunts blood from umbilical vein to IVCBecomes Ligamentum venosum
Foramen OvaleShunts blood from right to left atriumCloses after birth
Ductus ArteriosusConnects pulmonary artery to aortaBecomes Ligamentum arteriosum

Clinical Correlation:

  • Patent Ductus Arteriosus (PDA) leads to cyanosis, heart murmur.
  • Foramen ovale fails to close in 25% of people (may cause stroke in later life).

7. Clinical and Competitive Exam Importance

AspectClinical Relevance
Neural tube defectsDue to folic acid deficiency
First organ to developHeart (Week 4)
Viability of fetusPossible after 24 weeks
Lung maturationRequires surfactant (Week 28–36)
Patent Ductus ArteriosusCauses continuous murmur

8. Exam-Oriented Questions

Which organ develops first in the embryo?
👉 Heart (starts beating by Week 4)

At what week does quickening occur?
👉 Week 16

Which structure allows blood to bypass the lungs in fetal circulation?
👉 Ductus Arteriosus

What is the major cause of polyhydramnios?
👉 Esophageal Atresia

At what week is the fetus viable outside the womb?
👉 Week 24

Published
Categorized as COH MIDWIFERY, Uncategorised